Tau pathology and brain sulci in chronic traumatic encephalopathy

Takeaway

  • The astroglial component of chronic traumatic encephalopathy (CTE)-associated neuropathologic change preferentially distributes to cortical sulci depths, while the neuronal component distributes more uniformly from gyral crest to sulcal depth.

Why this matters

  • Current diagnostic criteria for neuropathologic evaluation of CTE (traumatic brain injury [TBI]-related neurodegeneration) define tau-immunoreactive neuronal and astroglial profiles in a patchy cortical distribution, but do not describe the distribution of specific cellular components.

  • The distribution of astroglial and neuronal tau-related pathology in CTE provides new insights distinguishing it from other tauopathies and suggests a potential need for the reviewing and refining of current diagnostic criteria.