Tau pathology in anti-IgLON5 disease: a new piece of the puzzle


  • Case study of a patient with anti-IgLON5 disease reveals an absence of brainstem tau pathology and a neuropathologic profile consistent with moderate Alzheimer’s disease (AD).

Why this matters

  • Anti-IgLON5 is a novel neurodegenerative disease associated with antibodies against the neuronal cell-adhesion protein IgLON5, and is characterized by sleep disturbance, gait instability and bulbar symptoms.

  • Brainstem tauopathy was documented in the first case of anti-IgLON5, yet there is uncertainty as to whether this is a typical neuropathologic feature of the disease.

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.