Tau pathology patterns differentiate between typical and atypical Alzheimer’s disease

Takeaway

  • Clinical phenotypes of Alzheimer’s disease are linked to specific patterns of tau, but not amyloid, pathology.

Why this matters

    There is an unmet need to characterize the heterogeneity of Alzheimer’s disease to enable individualized treatment. These novel findings elucidate the underlying neuropathological mechanisms of this heterogeneity and could enable the development of disease biomarker and targeted treatment.