Summary Summary Short summary of a recent publication, written by scientific experts. Published: Nov 24, 2018

The APOE ε4 allele is a risk factor for transactive response DNA-binding protein 43 aggregation

Takeaway

  • In Alzheimer’s disease (AD) patients, the Apolipoprotein E (APOE) ε4 allele was associated both directly and indirectly with transactive response DNA-binding protein 43 (TDP-43) aggregation and hippocampal sclerosis.

Why this matters

  • The APOE ε4 allele and TDP-43 are associated with cognitive decline in AD however their association with each other is unknown.