The brain–thymus crosstalk on immunosuppression in experimental brain cancers


  • GL261 glioma mice are a valuable model for studying immunosuppression mechanisms as they exhibit features of peripheral immunosuppression similar to patients with glioblastoma.

Why this matters

  • One of the hallmarks of glioblastoma is immunosuppression of unknown etiology and is characterised by low CD4 T-cells and downregulation of MHC II expression on monocytes.

  • This study attempts to mimic immunosuppression observed in patients with glioblastoma in mouse models to further our understanding of this feature in order to develop immunotherapies for glioblastoma.