The cerebellum and cognition in corticobasal syndrome and progressive supranuclear palsy

Takeaway

  • Support for the established role of the Crus I cerebellar region in executive function, and further evidence for vermal involvement in cognitive processing in corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are provided.

Why this matters

  • Research increasingly suggests a link between cerebellar atrophy and cognitive deficit in the major frontotemporal dementia syndromes; however, it is unclear whether this is evident in their associated motor syndromes, including CBS and PSP.

  • The role of cerebellar atrophy in cognitive decline in CBS and PSP may constitute potential diagnostic and surveillance biomarkers of these conditions, directing treatment strategies and positively impacting patient outcomes and quality of life.