Acute exercise reduces plasma neurofilament light chain (pNfL) levels potentially alleviating the ongoing neurodegeneration in multiple sclerosis (MS), with high-intensity interval training (HIIT) leading to greater responses compared with moderate continuous training (MCT).
Why this matters
Higher levels of pNfL, a peripheral blood biomarker of neurodegeneration, are associated with neuroinflammation and disability progression in persons with MS (pwMS).
Recent evidence suggests that pNfL levels are positively associated with the kynurenine (KYN) pathway which is also involved in neuroinflammation and neurodegeneration, and is deregulated in pwMS.
It is known that physical exercise has a positive effect on MS symptoms but more research is needed into its disease-modifying effects to enable the development of targeted exercise recommendations for pwMS.