The effects of optic neuritis in aquaporin-4 IgG seropositive patients with neuromyelitis optica spectrum disorder


  • It is important to prevent optic neuritis (ON) attack in neuromyelitis optica spectrum disorder (NMOSD) to avoid severe neuroaxonal damage and loss of vision.

Why this matters ?

  • Patients with NMOSD can experience recurrent ON attacks, which causes vision loss.

  • There are at least 3 subtypes of NMOSD based on serostatus, one of which is sero-positivity for anti-aquaporin-4 IgG (AQP4-IgG).

  • However, correlation between serologic phenotypes and clinical manifestation, including subclinical retinal degradation and vision loss are unclear.