It is important to prevent optic neuritis (ON) attack in neuromyelitis optica spectrum disorder (NMOSD) to avoid severe neuroaxonal damage and loss of vision.
Why this matters
Patients with NMOSD can experience recurrent ON attacks, which causes vision loss.
There are at least 3 subtypes of NMOSD based on serostatus, one of which is sero-positivity for anti-aquaporin-4 IgG (AQP4-IgG).
However, correlation between serologic phenotypes and clinical manifestation, including subclinical retinal degradation and vision loss are unclear.