The genetic contribution to common epilepsy and its subtypes


  • Polygenic risk scores (PRS) explain more of the genetic variance in idiopathic generalized epilepsy (IGE) compared to nonacquired focal epilepsy (NAFE).

Why this matters ?

  • The complex genetic mechanisms underlying epilepsy are not fully understood.

  • Epilepsy should be stratified by subtype when researching the genetic mechanisms of disease.