The influence of genetic factors on humoral response toward EBNA-1 in multiple sclerosis

Takeaway

  • There is a strong genetic influence on the Epstein-Barr virus nuclear antigen 1 (EBNA-1) response that is partially associated with HLA-DRB1*1501, as evidenced by the highest levels of EBNA-1 immunoglobulin (IgG) gradient in patients with multiple sclerosis (MS), intermediate levels in siblings, and lowest in spouses of families with MS; additional genetic factors likely contribute to EBNA-1 IgG levels.

Why this matters

    Studies have shown a strong genetic association between HLA-DRB1*1501 and MS risk, but the impact of host genetic factors on immune response to Epstein Barr Virus is not yet fully understood. Understanding this relationship will aid in the diagnosis and care of patients with MS.