The longitudinal role of Type 2 diabetes mellitus in brain atrophy and cognitive decline

Takeaway

  • Type 2 diabetes mellitus (T2DM) was indirectly related to greater cognitive decline via an association with lower levels of cortical thickness at baseline.

Why this matters

  • The contribution of T2DM to brain atrophy and cognitive decline over time is not known and may represent an important risk factor which can be targeted for prevention of dementia.