The predictive value of cognitive performance for Alzheimer’s dementia neuropathology


  • Neuropsychological test performance is associated with neuropathological outcomes in Alzheimer’s dementia (AD).

Why this matters

  • AD is a clinically heterogenous disease and the biological pathways involved in the development and progression of cognitive decline are not completely recognized. This hinders early identification and treatment of affected individuals.

  • Predicting the underlying pathology of AD may advance diagnosis, inform prognosis, and guide treatment at early stages of cognitive impairment and dementia.