The PROMIS SF v1.0 – Fatigue (multiple sclerosis) 8a: a newly validated test for fatigue in multiple sclerosis


  • The PROMIS Fatigue (multiple sclerosis) 8a instrument has strong validity, test-retest reliability and responsiveness in a US–UK population with multiple sclerosis.

Why this matters

  • Although fatigue is a major disabling symptom of multiple sclerosis, there is a lack of consensus on optimal fatigue measures in clinical practice. This important study extends the evidence supporting the content validity and the robust psychometric performance of the PROMIS Fatigue (MS) 8a across both US and UK multiple sclerosis populations.