The protein C pathway and brain volume in people with multiple sclerosis

Takeaway

  • Circulating protein C (PC) levels are indicative of more severe neurodegeneration in people with multiple sclerosis (MS) with potential dysregulation of the pathway in this group compared with controls.

Why this matters

    Hemostatic factors in the central nervous system sustain inflammatory responses and immune activation and involvement of the PC pathway in MS has been suggested, these results suggest that further study of these pathways may elucidate mechanisms involved in neurodegeneration and identification of therapeutic targets.