The relationship between cognitive and motor impairment in people with amyotrophic lateral sclerosis


  • Cognitive impairment is more common in people with advanced stages of amyotrophic lateral sclerosis (ALS).

  • Bulbar involvement is associated with increased cognitive impairment at all stages of disease.

Why this matters

  • There has previously been difficulty evaluating cognitive function in people with ALS, due to the progressive loss of speech and motor function.

  • These findings support the hypothesis that ALS progresses sequentially, via a cortico-efferent spreading model.