The relationship between proliferation activity and central nervous system invasion in meningiomas


  • Meningiomas with pathological central nervous system (CNS) invasion showed higher proliferative activity, compared with patients without the invasion.

Why this matters

  • Between 20 and 47% of patients with meningiomas experienced recurrence, hence, it is important to identify patients with increasing risk of recurrence for guiding the post-operative management.

  • CNS invasion in meningiomas has been integrated into the WHO classification for CNS tumors since 2016, while the prognostic impact of CNS invasion has been limited because the current evidence is mainly based on controversial results of retrospective analyses.