An increase in the retinal inner nuclear layer (INL) volume was associated with multiple sclerosis optic neuritis (MSON) and the occurrence of clinical relapse.
Why this matters
It is well established that the thickness of both peripapillary retinal nerve fiber and the ganglion cell-inner plexiform layer is associated with the neurodegeneration in multiple sclerosis (MS). The relationship of the INL with inflammatory disease activity is not as well understood. This study showed that volume changes of the INL during disease activity may be a useful indicator in the treatment of MS.