The Revised Self-Monitoring Scale as a clinical endpoint for frontotemporal dementia clinical trials

Takeaway

  • The level of disease severity and duration in individuals with behavioral variant frontotemporal dementia (bvFTD) correlated with ratings on the Revised Self-Monitoring Scale (RSMS) score. Longitudinal changes in RSMS score corresponded to progressive gray matter atrophy predominantly in the salience network (SN).

Why this matters

    bvFTD is characterized by deficits in behavior, language and motor function, as well as drastic alterations in social behavior. As the initial symptoms of bvFTD are solely behavioral, current clinical trials require psychometrically valid tests to detect the earliest socioemotional changes in individuals with pre-symptomatic bvFTD.