The role of antiplexin D1 antibodies in small fiber neuropathy


  • Although preliminary, the results of this study suggest that plexin D1-immunoglobulin G (D1-IgG) could be a potential biomarker for immunotherapy in patients with small fiber neuropathy (SFN).

Why this matters

  • SFN is characterized by neuropathic pain and autonomic symptoms, and in around half of the patients with this condition the cause is unknown.

  • The authors of this study have previously reported plexin D1-IgG in some patients with neuropathic pain and underlying neuroinflammatory diseases; in this study they provide further evidence for the role of antiplexin D1 antibodies in SFN.