The role of parkin interacting substrate in Parkinson’s disease pathology

Takeaway

  • In mouse models of Parkinson’s disease (PD), inactivation of the ubiquitin ligase, parkin, by c-Abelson (c-Abl) kinase leads to accumulation of parkin interacting substrate protein (PARIS), and knockout of PARIS alleviated the neurodegeneration observed in these models.

Why this matters

  • Suppression of PARIS may be a therapeutic strategy to halt progression of PD and other α-synucleinopathies.