The use of biomarkers to aid in the diagnosis of neurodegenerative disorders with Lewy pathology


  • Levels of the total-α-syn (t-α-syn) biomarker were significantly lower in people with Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), and Alzheimer’s disease (AD) versus controls, and the use of a t-tau/t-α-syn ratio improved diagnostic performance for these conditions over use of single biomarkers.

Why this matters

    Improved diagnostic tools, including a diagnostic biomarker panel, may lead to earlier and more accurate diagnoses of neurodegenerative disorders, thus improving patient management.