The white matter connectome in early Parkinson’s disease

Takeaway

  • A white matter (WM) connectome was identified for those with early Parkinson’s disease (PD) which was distinct from healthy controls (HC), characterized by increased structural connectivity and a core set of abnormalities.

Why this matters

    This study informs future investigations of the pathophysiology of PD as well as highlighting changes in structural connectivity which may be of interest in clinical trials of PD-modifying therapies.