Three-year safety and efficacy outcomes of focused ultrasound thalamotomy for essential tremor


  • At 3 years of follow-up, unilateral transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy demonstrates persistent, significant tremor reduction, accompanied by functional and quality of life (QOL) improvements, and a positive safety profile.

Why this matters

  • A previous randomized controlled trial (RCT) comparing tcMRgFUS thalamotomy to sham demonstrated tremor regression and improvements in disability and QOL that were sustained at 12 months, and a favorable safety profile; a follow-up study confirmed sustained outcomes at 24 months.

  • Demonstrating continued efficacy and safety after tcMRgFUS will aid patients and clinicians in making treatment decisions.

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