Time since injury is a key predictor of recovery in prolonged disorders of consciousness

Takeaway

  • Time since injury is an important predictor of Coma Recovery Scale-revised (CRS-R) trajectory; people with prolonged disorders of consciousness (DOC) show long-term improvements post-injury, extending beyond 2 years.

Why this matters

    In line with recently updated practice guidelines, these findings suggest that a diagnosis of permanence should not be made within the first 24 months post-ictus. Arousal could also influence neuroimaging assessments of consciousness and arousal interventions could have long-term therapeutic benefits.