Transcranial magnetic stimulation treatment on subgenual cingulate hyperactivity in depression


  • Transcranial magnetic stimulation (TMS) combined with electroencephalography demonstrates increased activity in the subgenual cingulate cortex (SGC) of people with major depressive disorder (MDD); active repetitive TMS (rTMS) attenuates this hyperactivity towards healthy levels.

Why this matters

  • Repetitive TMS appeared to alter the connectivity between the dorsolateral prefrontal cortex (DLPFC) and the SGC, suggesting that SGC is implicated in the pathophysiology of MDD. The findings highlight an objective biological target to differentiate mood states in this depression subtype.