TREM2 R47H variant risk on people with multiple sclerosis

Takeaway

  • The R47H variant of the triggering receptor expressed on myeloid cells 2 (TREM2) is not associated with multiple sclerosis (MS) risk in Greek populations.

Why this matters

  • R47H is the most studied variant of TREM2 and is associated with many neurological diseases, such as Alzheimer’s disease and frontotemporal dementia; however, it has never been studied in MS and may be a potential target for clinical therapies.