tRNA-derived fragments as potential biomarkers for Parkinson’s Disease


  • Transfer RNA (tRNA) fragments (tRFs) in the prefrontal cortex (PFC), cerebrospinal fluid (CSF), or serum samples can successfully distinguish patients with Parkinson’s Disease (PD) from healthy volunteers.

Why this matters

    tRNAs produce short non-coding RNAs called tRFs, which have been reported in biofluids and may serve as non-invasive biomarkers for PD that are needed to improve PD diagnosis.