Tumor control and survival following stereotactic radiosurgery for metastatic brain tumors


  • High local tumor control can be achieved with stereotactic radiosurgery (SRS) independent of the number of metastases treated at once; a high number of metastatic brain tumors should not rule out SRS, and metachronous treatment is not inferior to synchronous treatment.

Why this matters

  • There are few reports of survival, tumor control achieved, and brain volume exposed to 12 grays (V12Gy) with SRS alone, rather than whole brain radiation therapy (WBRT), to treat ≥10 brain metastases.

  • This study shows that SRS is highly precise, with relative sparing of nearby tissue and decreased neurocognitive morbidity compared with WBRT.