Understanding the mechanisms that drive heterogeneity in Alzheimer’s disease


  • Alzheimer’s disease (AD) typicality and severity were identified as the two core drivers of AD heterogeneity that may determine which AD subtype an individual will belong to. Expanding on this finding, the authors proposed a model that can be used alongside the A/T/N classification scheme to aid with: forming hypotheses, developing study designs, interpreting results and understanding AD subtypes in future AD research.

Why this matters

  • AD typicality and severity may determine the likelihood a patient with AD will ultimately belong in one of the four main AD subtypes identified in this study: typical, limbic-predominant, hippocampal-sparing and minimal atrophy AD.

  • Better understanding AD heterogeneity is vital to developing precision medicine approaches for successfully treating AD.