Grey matter atrophy progresses with a specific pattern in spinocerebellar ataxia type 3.
Why this matters
These important findings show that neurodegeneration begins prior to clinical ataxic signs in spinocerebellar ataxia type 3. This provides valuable information about the natural history of structural damage in this disorder and confirms recognized clinical features. This unique insight into the ordered sequential process of regional brain atrophy could ultimately lead to targeted therapeutic strategies.