Use of amyloid positron emission technology to predict symptom onset in sporadic Alzheimer’s disease


  • The age when symptoms occur in Alzheimer’s disease (AD) is strongly correlated with the age when a tipping point in amyloid accumulation is reached.

Why this matters

    Brain amyloid accumulation does not occur linearly but reaches a threshold level after which amyloid accumulation increases and becomes fairly consistent. This study provides evidence that can facilitate identification of the age at which cognitively normal participants may advance to symptomatic AD, improving AD clinical trials and, ultimately, treatment.