Use of longitudinal quantitative MRI to assess structural changes in adrenomyeloneuropathy subjects


  • In adrenomyeloneuropathy (AMN) subjects, but not control subjects, structural changes (in total cord areas [TCAs] at T1–T2, and spinal cord diffusion tensor imaging [DTI] metrics) were observed following longitudinal quantitative MRI analysis.

Why this matters

  • As novel drugs are soon to be examined in AMN, valid clinical and imaging outcome measures are eagerly sought; thus, the results reported in this study, indicating that TCAs and spinal cord DTI metrics can be considered as surrogate outcome measures in AMN, are of great value and may be of use in future AMN clinical trials as well as becoming an integral part of the AMN diagnosis process.