Use of sleep spindles as a biomarker for clinical outcomes in West syndrome


  • Sleep spindles are not associated with treatment of hypsarrhythmia or clinical outcomes of West syndrome; therefore, sleep spindles cannot be used as a biomarker for West syndrome in children.

Why this matters

  • Children with West syndrome can experience hypsarrhythmia during sleep, which may prevent the formation of sleep spindles.

  • Sleep spindles are thought to help with memory and learning; therefore, they may be an important clinical biomarker to predict long-term outcomes in West syndrome.