Using fast ripples to predict postsurgical seizure outcomes


  • Previous studies have indicated that fast ripple (FR) analysis may have low sensitivity due to suboptimal spatial sampling of the epileptogenic zone (EZ) and that overnight automatic detection of FR results in more accurate outcome prediction than short visual analysis.

Why this matters

  • High frequency oscillations (HFO) are characterized by ripples, and FRs and may be a new biomarker of epilepsy that may indicate the EZ and may be a potential postsurgical seizure outcome.

  • Past surgical seizure studies analyzing HFO have analyzed short segments, which deemed this outcome to have low sensitivity; however, because FRs are affected by sleep stage, medication, and seizure activity, longer periods of measurement are required.