Neuroinflammatory signatures may exist in patients with different clinical presentations of chronic low back pain, offering potential targets for personalized pain therapy.
Why this matters
Neuro-immune responses, potentially mediated by microglia and astrocytes, are believed to play a key role in the pathogenesis and persistence of chronic low back pain.
Elevated levels of the 18kDa translocator protein (TPSO), a glial marker, have been found in the neural tissue of patients with several chronic pain conditions, including chronic low back pain, fibromyalgia, migraine, and Gulf War Illness.
It is possible that spatial differences in TPSO signals could help to characterize subtypes of patients with chronic low back pain.