Using PET to identify earlier stages of amyloid deposition in cognitively normal elderly people

Takeaway

  • Cognitively normal elderly individuals with high positron emission tomography (PET)-identified β-amyloid (Aβ) burden are at greater risk of cognitive decline.

Why this matters

    Identifying Aβ-negative people with cognitive decline using PET has proved problematic. These findings may provide a way to identify suitable early stage individuals for amyloid-lowering interventions.