Middle-aged adults with a family history of sporadic Alzheimer’s disease have elevated β-amyloid deposition as they approach parental age at symptom onset.
Why this matters
The role of risk and protective factors on imaging and cerebrospinal biomarkers in midlife is relatively unknown. These findings show that in cognitively unimpaired adults with a family history of Alzheimer’s disease, proximity to parental age at onset is linked to β-amyloid biomarkers. The identified biomarker changes and modifiable factors could enable earlier interventions in at-risk adults with a family history of Alzheimer’s disease.