β-γ phase-amplitude coupling is enhanced in Parkinson’s disease compared with healthy controls

Takeaway

  • Significantly higher phase-amplitude coupling illustrated in the hemisphere contralateral to the more clinically affected hemi body in patients with Parkinson’s disease.

Why this matters

  • It has been demonstrated previously that the amplitude of γ-band oscillations in the subthalamic nucleus, motor cortex, and the interactions between the two, is abnormally coupled to the phase of β-band oscillations in patients with Parkinson’s disease.

  • This enhanced phase-amplitude coupling has been proposed as a biomarker of Parkinson’s disease; however, the exact neuronal mechanisms that underly the abnormal coupling and its relationship to motor impairments in Parkinson’s disease remain unclear.