Takeaway
Significantly higher phase-amplitude coupling illustrated in the hemisphere contralateral to the more clinically affected hemi body in patients with Parkinson’s disease.
Why this matters
It has been demonstrated previously that the amplitude of γ-band oscillations in the subthalamic nucleus, motor cortex, and the interactions between the two, is abnormally coupled to the phase of β-band oscillations in patients with Parkinson’s disease.
This enhanced phase-amplitude coupling has been proposed as a biomarker of Parkinson’s disease; however, the exact neuronal mechanisms that underly the abnormal coupling and its relationship to motor impairments in Parkinson’s disease remain unclear.