Variants in motor neuron disease show different structural and functional changes

Takeaway

  • Individuals with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) show significant structural differences in the sensorimotor, basal ganglia, frontal and temporal regions, resulting in cognitive and motor impairments.

Why this matters

    The results can provide foundations for future network-based MRI studies into motor neuron disease (MND) and can be useful in identifying potential prognostic markers.