Variation in α-synuclein in two types of synucleinopathies indicated for the first time

Takeaway

  • Heterogeneity exists in the characteristics and seeding abilities of α-synuclein in dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) with dementia, potentially influencing treatment development.

Why this matters

  • It is not clear whether the synucleinopathies DLB and PD with dementia are different diseases or variants of the same disease spectrum.