Visual and cognitive assessment for multiple sclerosis in patients with clinically isolated syndrome optic neuritis


  • Patients with clinically isolated syndrome optic neuritis (ON-CIS) perform worse in visually dependent cognitive tests than visually non-dependent tests.

Why this matters

  • Clinically isolated syndrome (CIS) is one of the disease courses of multiple sclerosis (MS) and cognitive assessments have been used to determine a patient’s risk for developing MS.

  • Patients with CIS often present with optic neuritis (ON), which may impact cognitive assessments results, particularly those that have a visual component.

  • An assessment of patients with ON-CIS is important to determine the influence of visual impairment on cognitive function.