Voltage-gated sodium channel alpha subunit gene variants and postoperative pain

Takeaway

  • Voltage-gated sodium channel alpha subunit gene (SCN9A) variants are associated with acute pain perception, morphine consumption and the susceptibility to chronic pain.

Why this matters

    Study results suggest the potential role of SCN9A polymorphisms in determining pain outcomes, which could be further explored in the understanding of acute and chronic pain. If confirmed, the genetic associations could be used in conjunction with other predictive factors for patient risk stratification to improve clinical care.