Weighting of diagnostic criteria impacts classification of patients with mild cognitive impairment

Takeaway

  • The low rates of reversion in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) classification of mild cognitive impairment (MCI) may be driven by weighting of the subjective Clinical Dementia Rating (CDR) resulting in an artificial MCI diagnosis, despite normal memory and biomarkers.

Why this matters

    Further investigation is needed into ADNI’s MCI criteria to establish the basis for the very low 1-year MCI-to-cognitively normal (CN) reversion rate.