What is the impact of discontinuing acute medications in people with migraine?


  • Individuals who stop acute prescription medication for migraines have a significant unmet treatment need, with many unable to work or function normally when they have a headache.

Why this matters

  • Migraine affects 1 in 7 individuals worldwide and is associated with significant disability. In many individuals, however, available treatments are often ineffective, poorly tolerated or contraindicated, indeed excessive medication has also been associated with progression from episodic to chronic migraine; and many individuals are dissatisfied with their acute treatment. It is important to understand the impact of discontinuing acute treatment in these individuals so as to address concerns, improve outcomes and mitigate the societal burden of migraine.