Which is the best quantitative imaging biomarker for leg muscle degeneration in Becker muscular dystrophy?

Takeaway

  • Fat fraction of whole thigh three center slices represents the optimal biomarker in ambulant adults with Becker muscular dystrophy.

Why this matters

    Clinical trials in muscular dystrophies are hindered by the lack of objective biomarkers that are sensitive to disease progression, are reproducible, and are linked to functional assessments. The findings of this important study support the use of fat fractions quantified by quantitative magnetic resonance imaging as a biomarker in clinical trials in slowly progressive diseases, such as Becker muscular dystrophy.