White matter abnormalities in cognitively normal middle-aged and older adults


  • Amyloid-beta (Aβ) deposition is associated with an age-related increase in white matter abnormalities.

Why this matters

  • Aβ deposition precedes onset of Alzheimer’s disease (AD) and may be associated with age-related white matter abnormalities.

  • Pathological white matter changes constitute a core feature of AD pathogenesis.

  • Few studies have evaluated the relationship between Aβ deposition and white matter changes in middle-aged adults.