White matter changes and upper motor neuron impairment in patients with amyotrophic lateral sclerosis

Takeaway

  • Fixel-based analysis (FBA) may be useful to assess changes in the corticospinal tracts (CSTs) in patients with amyotrophic lateral sclerosis (ALS) and therefore, evaluate upper motor neuron involvement in ALS.

Why this matters

  • ALS is a severe neurodegenerative disease that involves the progressive loss of upper and lower motor neurons.

  • White matter abnormalities in the CSTs and corpus callosum (CC) are associated with upper motor neuron involvement in patients with ALS.

  • Unlike previous imaging analysis techniques, FBA is more specific in identifying fiber populations; however, the association between FBA metrics and upper motor neuron impairment in patients with ALS is unclear.

  • Therefore, research regarding CSTs and CC changes using FBA in patients with ALS is warranted.