White matter connectivity and autonomic dysfunction in early-stage Parkinson’s disease

Takeaway

  • In those with de novo Parkinson’s disease (PD), autonomic dysfunction is associated with disruptions in white matter connectivity.

Why this matters

  • Dysautonomia is a predictor for rapid motor decline in early-stage PD, and this study shows neuroimaging evidence of brain structural and functional alterations associated with dysautonomia.