White matter degeneration in Parkinson’s disease and genetic risk


  • Parkinson’s Disease (PD)-associated polygenic load may affect white matter (WM) microstructural degeneration, leading to poor cognition.

Why this matters

  • Several biological risk factors have been shown to closely associate with PD pathogenesis, including the recent identification of a number of high-risk single nucleotide polymorphisms (SNPs) that affect PD development and progression.

  • However, each individual SNP is associated with relatively limited influence on PD susceptibility. A polygenic risk score (PRS) that captures multiple genetic loci may be a better method of investigating the global genetic risk for a patient with PD.

  • PRS has previously been found to associate with onset and progression of PD.