Parkinson’s Disease (PD)-associated polygenic load may affect white matter (WM) microstructural degeneration, leading to poor cognition.
Why this matters
Several biological risk factors have been shown to closely associate with PD pathogenesis, including the recent identification of a number of high-risk single nucleotide polymorphisms (SNPs) that affect PD development and progression.
However, each individual SNP is associated with relatively limited influence on PD susceptibility. A polygenic risk score (PRS) that captures multiple genetic loci may be a better method of investigating the global genetic risk for a patient with PD.
PRS has previously been found to associate with onset and progression of PD.