White matter hyperintensities are not predictive for cognitive decline in Parkinson’s disease


  • White matter hyperintensities (WMH) were not associated with cognitive decline in de novo Parkinson’s disease (PD) patients and hence are ineffective as predictive markers.

Why this matters

  • Cognitive decline and impairment have a very high burden on individuals with PD.

  • 80% of newly diagnosed PD patients will develop dementia within 20 years; being able to predict disease progression would aid physician decision-making around care.